|
|
thebaine + 2-oxoglutarate + O2 <=> neopinone + formaldehyde + succinate + CO2
|
1.14.11.31
thebaine 6-O-demethylase
|
–
|
| |
BRENDA:
BR49145
KEGG:
R05126
MetaCyc:
RXN-8147
|
|
|
|
7-O-acetylsalutaridinol <=> H+ + thebaine + acetate
|
4.2.99.24
thebaine synthase
|
–
|
| |
BRENDA:
BR52702
KEGG:
R04769
MetaCyc:
RXN-8144
|
|
|
|
(S)-reticuline + O2 + reduced_[NADPH-hemoprotein_reductase] <=> 1,2-dehydroreticuline + H2O + oxidized_[NADPH-hemoprotein_reductase]
|
1.14.19.54
1,2-dehydroreticuline synthase
|
–
|
| |
MetaCyc:
RXN-8142
|
|
|
|
NADP+ + codeine <=> H+ + NADPH + codeinone
|
1.1.1.218
morphine 6-dehydrogenase
1.1.1.247
codeinone reductase (NADPH)
|
–
–
|
| |
BRENDA:
BR916
KEGG:
R05124
MetaCyc:
1.1.1.247-RXN
SABIO-RK:
4745
|
|
|
|
NADP+ + salutaridinol <=> H+ + NADPH + salutaridine
|
1.1.1.248
salutaridine reductase (NADPH)
|
–
|
| |
BRENDA:
BR917
KEGG:
R04697
MetaCyc:
1.1.1.248-RXN
|
|
|
|
thebaine + 2-oxoglutarate + O2 <=> oripavine + formaldehyde + succinate + CO2
|
1.14.11.32
codeine 3-O-demethylase
|
–
|
| |
BRENDA:
BS406754
KEGG:
R05127
MetaCyc:
RXN-8149
|
|
|
|
oripavine + 2-oxoglutarate + O2 <=> morphinone + formaldehyde + succinate + CO2
|
1.14.11.31
thebaine 6-O-demethylase
|
–
|
| |
BRENDA:
BS402808
KEGG:
R03698
MetaCyc:
RXN-8151
|
|
|
|
NADP+ + morphine <=> NADPH + morphinone + H+
|
1.1.1.218
morphine 6-dehydrogenase
1.1.1.247
codeinone reductase (NADPH)
|
–
–
|
| |
BRENDA:
BR29259
KEGG:
R03592
MetaCyc:
MORPHINE-6-DEHYDROGENASE-RXN
SABIO-RK:
3375
|
|
|
|
(R)-reticuline + NADP+ <=> 1,2-dehydroreticuline + NADPH + H+
|
1.5.1.27
1,2-dehydroreticulinium reductase (NADPH)
|
–
|
| |
BRENDA:
BR1298
KEGG:
R04695
MetaCyc:
1.5.1.27-RXN
|
|
|
|
salutaridinol + acetyl-CoA <=> 7-O-acetylsalutaridinol + CoA
|
2.3.1.150
salutaridinol 7-O-acetyltransferase
|
–
|
| |
BRENDA:
BR1626
KEGG:
R04723
MetaCyc:
2.3.1.150-RXN
|
|
|
|
(R)-reticuline + O2 + reduced_[NADPH-hemoprotein_reductase] <=> salutaridine + H2O + oxidized_[NADPH-hemoprotein_reductase]
|
1.14.19.67
salutaridine synthase
|
–
|
| |
MetaCyc:
1.1.3.35-RXN
|
|
|
|
codeine + 2-oxoglutarate + O2 <=> morphine + formaldehyde + succinate + CO2
|
1.14.11.32
codeine 3-O-demethylase
|
–
|
| |
BRENDA:
BR49146
KEGG:
R09402
MetaCyc:
RXN-8152
|
|
|
|
neopinone <=> codeinone
|
not assigned
|
–
|
| |
KEGG:
R05125
MetaCyc:
RXN-8150
|
|
